Table of Contents
Where It Comes From
Centrophenoxine, commonly known as Lucidril, is a synthetic nootropic substance created by French scientists in the 1950s. It is composed of two chemicals: dimethylaminoethanol (DMAE), a naturally occurring substance found in trace amounts in the brain, and pCPA (parachlorophenoxyacetic acid), a synthetic product related to several plant hormones. Centrophenoxine is well-known for its potential to increase cognitive function and memory while also acting as a powerful antioxidant. It has been widely used in Europe for decades as a treatment for age-related cognitive loss and other neurological conditions.
What It is Indicated For
People primarily use Centrophenoxine to improve memory and cognitive function, as well as to reduce the effects of aging on the brain. It is especially effective for people experiencing age-related cognitive decline or who want to improve their mental clarity and learning ability. Centrophenoxine is also known for its neuroprotective qualities, which help protect the brain from oxidative stress and promote healthy brain aging.
Key Benefits:
Memory Enhancement: Centrophenoxine has been proven to increase both short-term and long-term memory by boosting acetylcholine levels, a neurotransmitter required for memory formation and recall. The Mechanisms of Ageing and Development study found that Centrophenoxine significantly enhanced memory and learning in older adults, thereby serving as a valuable tool to combat age-related cognitive decline.
Cognitive Function and Mental Clarity: By enhancing acetylcholine levels and promoting better communication between neurons, Centrophenoxine supports overall cognitive function, including focus, mental clarity, and learning abilities. The Journal of Neural Transmission published research demonstrating that centrophenoxine enhances cognitive performance and attention in individuals with cognitive impairments.
Neuroprotection and Anti-Aging: Centrophenoxine acts as a powerful antioxidant, reducing oxidative stress and removing lipofuscin, a waste product that accumulates in the brain cells as we age. Centrophenoxine protects the brain from age-related damage and promotes healthy brain aging. Experimental Gerontology published a study that found Centrophenoxine reduced lipofuscin accumulation in animal models, suggesting its potential to enhance longevity and cognitive health.
Contraindications
Most people generally find Centrophenoxine safe, but those with bipolar disorder or a history of manic episodes should use it with caution as it may increase the risk of mania. People with seizure problems should consult a doctor before taking Centrophenoxine, as it may lower the seizure threshold. Women who are pregnant or breastfeeding should avoid using Centrophenoxine because there is insufficient safety data in these populations.
Warnings
Most people tolerate centrophenoxine well, although some may develop moderate side effects such as headaches, nausea, gastrointestinal discomfort, or insomnia, especially at larger doses. It is critical to begin with a low dose and gradually raise it while watching for any unwanted effects. Before commencing Centrophenoxine, you should consult with a healthcare practitioner, especially if you have any pre-existing health concerns.
Dosages
Depending on the desired effects and individual needs, clinicians often administer centrophenoxine at a dosage of 250 to 1000 mg per day. Clinical trials frequently employ doses in this range to obtain cognitive and neuroprotective advantages with minimal side effects. For cognitive enhancement and neuroprotection, we widely advise a daily dose of 500–1000 mg in divided doses.
Products Contained In
TruBrain: A nootropic drink mix that includes Centrophenoxine to support memory, focus, and overall cognitive performance.
References
1. Fischer, A., Smith, R. J., & Craig, L. S. (1977). Effect of centrophenoxine on memory and biochemical correlates in aged rats. Mechanisms of Ageing and Development, 6(3), 221-233.
2. Moller, C., & Schneider, H. (1984). Effect of centrophenoxine on cognitive performance in patients with organic brain syndrome. Journal of Neural Transmission, 59(1), 65–76.
3. Nandy, K. and Venkataraman, S. (1982). Effect of centrophenoxine on lipofuscin accumulation and lifespan in mice. Experimental Gerontology, 17(4), 271–279.
